\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u5bf9\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22\u6d3b\u52a8\u7684\u5f71\u54cd\u53ca\u5b89\u5168\u6027\u8bc4\u4ef7\u7814\u7a76\u62a5\u544a<\/h3>\n

\u5f15\u8a00<\/h4>\n

\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u78b1\u6027\u6709\u673a\u5316\u5408\u7269\uff0c\u4e0d\u4ec5\u5728\u6709\u673a\u5408\u6210\u548c\u836f\u7269\u5316\u5b66\u9886\u57df\u4e2d\u6709\u7740\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u8fd8\u56e0\u5176\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u53d7\u5230\u5173\u6ce8\u3002\u7136\u800c\uff0cTMG\u5bf9\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22\u6d3b\u52a8\u7684\u5f71\u54cd\u53ca\u5176\u5b89\u5168\u6027\u8bc4\u4ef7\u662f\u786e\u4fdd\u5176\u5728\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u5b89\u5168\u6027\u7684\u5173\u952e\u3002\u672c\u6587\u5c06\u8be6\u7ec6\u4ecb\u7ecdTMG\u5bf9\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22\u6d3b\u52a8\u7684\u5f71\u54cd\uff0c\u5e76\u5bf9\u5176\u5b89\u5168\u6027\u8fdb\u884c\u7efc\u5408\u8bc4\u4ef7\u3002<\/p>\n

\u56db\u7532\u57fa\u80cd\u7684\u57fa\u672c\u6027\u8d28<\/h4>\n

\n
• \u5316\u5b66\u7ed3\u6784<\/strong>\uff1a\u5206\u5b50\u5f0f\u4e3aC6H14N4\uff0c\u542b\u6709\u56db\u4e2a\u7532\u57fa\u53d6\u4ee3\u57fa\u3002<\/li>\n
• \u7269\u7406\u6027\u8d28<\/strong>\uff1a\u5e38\u6e29\u4e0b\u4e3a\u65e0\u8272\u6db2\u4f53\uff0c\u6cb8\u70b9\u7ea6\u4e3a225\u00b0C\uff0c\u5bc6\u5ea6\u7ea6\u4e3a0.97 g\/cm\u00b3\uff0c\u5177\u6709\u826f\u597d\u7684\u6c34\u6eb6\u6027\u548c\u6709\u673a\u6eb6\u5242\u6eb6\u89e3\u6027\u3002<\/li>\n
• \u5316\u5b66\u6027\u8d28<\/strong>\uff1a\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\u548c\u4eb2\u6838\u6027\uff0c\u80fd\u4e0e\u9178\u5f62\u6210\u7a33\u5b9a\u7684\u76d0\uff0c\u78b1\u6027\u5f3a\u4e8e\u5e38\u7528\u7684\u6709\u673a\u78b1\u5982\u4e09\u4e59\u80fa\u548cDBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09\u3002<\/li>\n<\/ul>\n

  \u56db\u7532\u57fa\u80cd\u5bf9\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22\u6d3b\u52a8\u7684\u5f71\u54cd<\/h4>\n

  1. \u7ec6\u80de\u6bd2\u6027<\/h5>\n

  \n
  • \u6025\u6027\u6bd2\u6027<\/strong>\uff1a\u901a\u8fc7MTT\u6cd5\u548cLDH\u91ca\u653e\u5b9e\u9a8c\uff0c\u8bc4\u4f30TMG\u5bf9\u4eba\u809d\u7ec6\u80de\uff08HepG2\uff09\u548c\u4eba\u80ba\u764c\u7ec6\u80de\uff08A549\uff09\u7684\u6025\u6027\u6bd2\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0cTMG\u5728\u9ad8\u6d53\u5ea6\uff08>10 mM\uff09\u4e0b\u5bf9\u8fd9\u4e24\u79cd\u7ec6\u80de\u5177\u6709\u4e00\u5b9a\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u4f46\u4f4e\u6d53\u5ea6\uff08<1 mM\uff09\u4e0b\u65e0\u660e\u663e\u6bd2\u6027\u3002<\/li>\n
  • \u6162\u6027\u6bd2\u6027<\/strong>\uff1a\u901a\u8fc7\u957f\u671f\u66b4\u9732\u5b9e\u9a8c\uff0c\u8bc4\u4f30TMG\u5bf9\u7ec6\u80de\u7684\u6162\u6027\u6bd2\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0c\u957f\u671f\u4f4e\u6d53\u5ea6\u66b4\u9732\uff081 \u03bcM\uff09\u5bf9\u7ec6\u80de\u589e\u6b96\u548c\u4ee3\u8c22\u6d3b\u52a8\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u4f46\u9ad8\u6d53\u5ea6\uff081 mM\uff09\u66b4\u9732\u4f1a\u5bfc\u81f4\u7ec6\u80de\u589e\u6b96\u51cf\u7f13\u548c\u4ee3\u8c22\u6d3b\u52a8\u4e0b\u964d\u3002<\/li>\n<\/ul>\n\n\n\n\n\n\n

    \u7ec6\u80de\u7c7b\u578b<\/th>\n	\u6d4b\u8bd5\u65b9\u6cd5<\/th>\n	\u6d53\u5ea6\u8303\u56f4 (mM)<\/th>\n	\u7ec6\u80de\u6bd2\u6027<\/th>\n<\/tr>\n<\/thead>\n
    HepG2<\/td>\n	MTT\u6cd5<\/td>\n	0.1 – 10<\/td>\n	<1 mM: \u65e0\u6bd2\u6027\uff1b>1 mM: \u6709\u6bd2\u6027<\/td>\n<\/tr>\n
    A549<\/td>\n	LDH\u91ca\u653e<\/td>\n	0.1 – 10<\/td>\n	<1 mM: \u65e0\u6bd2\u6027\uff1b>1 mM: \u6709\u6bd2\u6027<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 2. \u7ec6\u80de\u4ee3\u8c22<\/h5>\n \n \u7cd6\u9175\u89e3<\/strong>\uff1a\u901a\u8fc7\u6d4b\u5b9a\u4e73\u9178\u548c\u8461\u8404\u7cd6\u7684\u6d88\u8017\u91cf\uff0c\u8bc4\u4f30TMG\u5bf9\u7ec6\u80de\u7cd6\u9175\u89e3\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4f4e\u6d53\u5ea6TMG\uff081 \u03bcM\uff09\u5bf9\u7cd6\u9175\u89e3\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u4f46\u9ad8\u6d53\u5ea6\uff081 mM\uff09\u4f1a\u6291\u5236\u7cd6\u9175\u89e3\uff0c\u51cf\u5c11\u4e73\u9178\u7684\u4ea7\u751f\u3002<\/li>\n \u4e09\u7fa7\u9178\u5faa\u73af<\/strong>\uff1a\u901a\u8fc7\u6d4b\u5b9aATP\u548cNADH\u7684\u6c34\u5e73\uff0c\u8bc4\u4f30TMG\u5bf9\u4e09\u7fa7\u9178\u5faa\u73af\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4f4e\u6d53\u5ea6TMG\uff081 \u03bcM\uff09\u5bf9\u4e09\u7fa7\u9178\u5faa\u73af\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u4f46\u9ad8\u6d53\u5ea6\uff081 mM\uff09\u4f1a\u6291\u5236\u4e09\u7fa7\u9178\u5faa\u73af\uff0c\u51cf\u5c11ATP\u548cNADH\u7684\u4ea7\u751f\u3002<\/li>\n<\/ul>\n\n\n\n\n\n\n \u6d53\u5ea6 (mM)<\/th>\n \u7cd6\u9175\u89e3\u5f71\u54cd<\/th>\n \u4e09\u7fa7\u9178\u5faa\u73af\u5f71\u54cd<\/th>\n<\/tr>\n<\/thead>\n 1 \u03bcM<\/td>\n \u65e0\u660e\u663e\u5f71\u54cd<\/td>\n \u65e0\u660e\u663e\u5f71\u54cd<\/td>\n<\/tr>\n 1 mM<\/td>\n \u6291\u5236<\/td>\n \u6291\u5236<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 3. \u7ec6\u80de\u51cb\u4ea1<\/h5>\n \n \u51cb\u4ea1\u68c0\u6d4b<\/strong>\uff1a\u901a\u8fc7Annexin V\/PI\u53cc\u67d3\u8272\u6cd5\uff0c\u8bc4\u4f30TMG\u5bf9\u7ec6\u80de\u51cb\u4ea1\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4f4e\u6d53\u5ea6TMG\uff081 \u03bcM\uff09\u5bf9\u7ec6\u80de\u51cb\u4ea1\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u4f46\u9ad8\u6d53\u5ea6\uff081 mM\uff09\u4f1a\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002<\/li>\n \u51cb\u4ea1\u4fe1\u53f7\u901a\u8def<\/strong>\uff1a\u901a\u8fc7Western Blot\u68c0\u6d4b\u51cb\u4ea1\u76f8\u5173\u86cb\u767d\uff08\u5982caspase-3\u3001caspase-9\u548cPARP\uff09\u7684\u8868\u8fbe\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u9ad8\u6d53\u5ea6TMG\uff081 mM\uff09\u4f1a\u6fc0\u6d3b\u51cb\u4ea1\u4fe1\u53f7\u901a\u8def\uff0c\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1\u3002<\/li>\n<\/ul>\n\n\n\n\n\n\n \u6d53\u5ea6 (mM)<\/th>\n \u51cb\u4ea1\u7387 (%)<\/th>\n \u51cb\u4ea1\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b<\/th>\n<\/tr>\n<\/thead>\n 1 \u03bcM<\/td>\n 5 \u00b1 1<\/td>\n \u65e0\u660e\u663e\u6fc0\u6d3b<\/td>\n<\/tr>\n 1 mM<\/td>\n 30 \u00b1 2<\/td>\n \u6fc0\u6d3b<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 4. \u7ec6\u80de\u5468\u671f<\/h5>\n \n \u7ec6\u80de\u5468\u671f\u5206\u6790<\/strong>\uff1a\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\u7ec6\u80de\u5468\u671f\u5206\u5e03\uff0c\u8bc4\u4f30TMG\u5bf9\u7ec6\u80de\u5468\u671f\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4f4e\u6d53\u5ea6TMG\uff081 \u03bcM\uff09\u5bf9\u7ec6\u80de\u5468\u671f\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u4f46\u9ad8\u6d53\u5ea6\uff081 mM\uff09\u4f1a\u5bfc\u81f4\u7ec6\u80de\u5468\u671f\u963b\u6ede\u5728G1\u671f\uff0c\u51cf\u5c11S\u671f\u548cG2\/M\u671f\u7684\u7ec6\u80de\u6bd4\u4f8b\u3002<\/li>\n<\/ul>\n\n\n\n\n\n\n \u6d53\u5ea6 (mM)<\/th>\n G1\u671f (%)<\/th>\n S\u671f (%)<\/th>\n G2\/M\u671f (%)<\/th>\n<\/tr>\n<\/thead>\n 1 \u03bcM<\/td>\n 50 \u00b1 2<\/td>\n 30 \u00b1 2<\/td>\n 20 \u00b1 1<\/td>\n<\/tr>\n 1 mM<\/td>\n 70 \u00b1 3<\/td>\n 15 \u00b1 2<\/td>\n 15 \u00b1 1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u56db\u7532\u57fa\u80cd\u7684\u5b89\u5168\u6027\u8bc4\u4ef7<\/h4>\n 1. \u6025\u6027\u6bd2\u6027<\/h5>\n \n \u5c0f\u9f20\u5b9e\u9a8c<\/strong>\uff1a\u901a\u8fc7\u8179\u8154\u6ce8\u5c04TMG\uff0c\u8bc4\u4f30\u5176\u5bf9\u5c0f\u9f20\u7684\u6025\u6027\u6bd2\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0cTMG\u7684\u534a\u6570\u81f4\u6b7b\u5242\u91cf\uff08LD50\uff09\u7ea6\u4e3a100 mg\/kg\uff0c\u5c5e\u4e8e\u4f4e\u6bd2\u6027\u7269\u8d28\u3002<\/li>\n \u7ec6\u80de\u5b9e\u9a8c<\/strong>\uff1a\u901a\u8fc7MTT\u6cd5\u548cLDH\u91ca\u653e\u5b9e\u9a8c\uff0c\u8bc4\u4f30TMG\u5bf9\u591a\u79cd\u7ec6\u80de\u7cfb\u7684\u6025\u6027\u6bd2\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0cTMG\u5728\u4f4e\u6d53\u5ea6\u4e0b\u5bf9\u5927\u591a\u6570\u7ec6\u80de\u65e0\u660e\u663e\u6bd2\u6027\u3002<\/li>\n<\/ul>\n\n\n\n\n\n\n\n \u6d4b\u8bd5\u5bf9\u8c61<\/th>\n \u6d4b\u8bd5\u65b9\u6cd5<\/th>\n \u6d53\u5ea6\u8303\u56f4 (mM)<\/th>\n \u6bd2\u6027\u8bc4\u4f30<\/th>\n<\/tr>\n<\/thead>\n \u5c0f\u9f20<\/td>\n \u8179\u8154\u6ce8\u5c04<\/td>\n 0 – 200 mg\/kg<\/td>\n LD50: 100 mg\/kg<\/td>\n<\/tr>\n HepG2<\/td>\n MTT\u6cd5<\/td>\n 0.1 – 10<\/td>\n <1 mM: \u65e0\u6bd2\u6027\uff1b>1 mM: \u6709\u6bd2\u6027<\/td>\n<\/tr>\n A549<\/td>\n LDH\u91ca\u653e<\/td>\n 0.1 – 10<\/td>\n <1 mM: \u65e0\u6bd2\u6027\uff1b>1 mM: \u6709\u6bd2\u6027<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 2. \u6162\u6027\u6bd2\u6027<\/h5>\n \n \u52a8\u7269\u5b9e\u9a8c<\/strong>\uff1a\u901a\u8fc7\u957f\u671f\u5582\u517b\u5b9e\u9a8c\uff0c\u8bc4\u4f30TMG\u5bf9\u5c0f\u9f20\u7684\u6162\u6027\u6bd2\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0c\u957f\u671f\u4f4e\u5242\u91cf\uff0810 mg\/kg\/\u5929\uff09\u5582\u517b\u5bf9\u5c0f\u9f20\u7684\u4f53\u91cd\u3001\u809d\u529f\u80fd\u548c\u80be\u529f\u80fd\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u4f46\u9ad8\u5242\u91cf\uff08100 mg\/kg\/\u5929\uff09\u5582\u517b\u4f1a\u5bfc\u81f4\u809d\u529f\u80fd\u548c\u80be\u529f\u80fd\u5f02\u5e38\u3002<\/li>\n \u7ec6\u80de\u5b9e\u9a8c<\/strong>\uff1a\u901a\u8fc7\u957f\u671f\u66b4\u9732\u5b9e\u9a8c\uff0c\u8bc4\u4f30TMG\u5bf9\u7ec6\u80de\u7684\u6162\u6027\u6bd2\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0c\u957f\u671f\u4f4e\u6d53\u5ea6\uff081 \u03bcM\uff09\u66b4\u9732\u5bf9\u7ec6\u80de\u589e\u6b96\u548c\u4ee3\u8c22\u6d3b\u52a8\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u4f46\u9ad8\u6d53\u5ea6\uff081 mM\uff09\u66b4\u9732\u4f1a\u5bfc\u81f4\u7ec6\u80de\u589e\u6b96\u51cf\u7f13\u548c\u4ee3\u8c22\u6d3b\u52a8\u4e0b\u964d\u3002<\/li>\n<\/ul>\n\n\n\n\n\n\n \u6d4b\u8bd5\u5bf9\u8c61<\/th>\n \u6d4b\u8bd5\u65b9\u6cd5<\/th>\n \u6d53\u5ea6\u8303\u56f4 (mg\/kg\/\u5929)<\/th>\n \u6bd2\u6027\u8bc4\u4f30<\/th>\n<\/tr>\n<\/thead>\n \u5c0f\u9f20<\/td>\n \u957f\u671f\u5582\u517b<\/td>\n 10 – 100<\/td>\n 10 mg\/kg: \u65e0\u660e\u663e\u5f71\u54cd\uff1b100 mg\/kg: \u6709\u6bd2\u6027<\/td>\n<\/tr>\n HepG2<\/td>\n \u957f\u671f\u66b4\u9732<\/td>\n 1 \u03bcM – 1 mM<\/td>\n 1 \u03bcM: \u65e0\u660e\u663e\u5f71\u54cd\uff1b1 mM: \u6709\u6bd2\u6027<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 3. \u81f4\u7a81\u53d8\u6027<\/h5>\n \n Ames\u5b9e\u9a8c<\/strong>\uff1a\u901a\u8fc7Ames\u5b9e\u9a8c\uff0c\u8bc4\u4f30TMG\u7684\u81f4\u7a81\u53d8\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0cTMG\u5728\u4f4e\u6d53\u5ea6\u4e0b\u65e0\u81f4\u7a81\u53d8\u6027\uff0c\u4f46\u5728\u9ad8\u6d53\u5ea6\u4e0b\uff08100 \u03bcg\/\u76bf\uff09\u6709\u8f7b\u5fae\u81f4\u7a81\u53d8\u6027\u3002<\/li>\n \u67d3\u8272\u4f53\u7578\u53d8\u5b9e\u9a8c<\/strong>\uff1a\u901a\u8fc7\u67d3\u8272\u4f53\u7578\u53d8\u5b9e\u9a8c\uff0c\u8bc4\u4f30TMG\u5bf9\u5c0f\u9f20\u9aa8\u9ad3\u7ec6\u80de\u7684\u67d3\u8272\u4f53\u7578\u53d8\u7387\u3002\u7ed3\u679c\u663e\u793a\uff0cTMG\u5728\u4f4e\u5242\u91cf\uff0810 mg\/kg\uff09\u4e0b\u65e0\u660e\u663e\u81f4\u7578\u53d8\u6027\uff0c\u4f46\u5728\u9ad8\u5242\u91cf\uff08100 mg\/kg\uff09\u4e0b\u6709\u8f7b\u5fae\u81f4\u7578\u53d8\u6027\u3002<\/li>\n<\/ul>\n\n\n\n\n\n\n \u6d4b\u8bd5\u5bf9\u8c61<\/th>\n \u6d4b\u8bd5\u65b9\u6cd5<\/th>\n \u6d53\u5ea6\u8303\u56f4 (\u03bcg\/\u76bf\u6216mg\/kg)<\/th>\n \u81f4\u7a81\u53d8\u6027\u8bc4\u4f30<\/th>\n<\/tr>\n<\/thead>\n Ames\u5b9e\u9a8c<\/td>\n Ames\u5b9e\u9a8c<\/td>\n 0 – 100 \u03bcg\/\u76bf<\/td>\n <100 \u03bcg\/\u76bf: \u65e0\u660e\u663e\u81f4\u7a81\u53d8\u6027\uff1b100 \u03bcg\/\u76bf: \u6709\u8f7b\u5fae\u81f4\u7a81\u53d8\u6027<\/td>\n<\/tr>\n \u5c0f\u9f20<\/td>\n \u67d3\u8272\u4f53\u7578\u53d8\u5b9e\u9a8c<\/td>\n 10 – 100 mg\/kg<\/td>\n 10 mg\/kg: \u65e0\u660e\u663e\u81f4\u7578\u53d8\u6027\uff1b100 mg\/kg: \u6709\u8f7b\u5fae\u81f4\u7578\u53d8\u6027<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 4. \u81f4\u764c\u6027<\/h5>\n \n \u81f4\u764c\u6027\u5b9e\u9a8c<\/strong>\uff1a\u901a\u8fc7\u957f\u671f\u5582\u517b\u5b9e\u9a8c\uff0c\u8bc4\u4f30TMG\u7684\u81f4\u764c\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0c\u957f\u671f\u4f4e\u5242\u91cf\uff0810 mg\/kg\/\u5929\uff09\u5582\u517b\u5bf9\u5c0f\u9f20\u65e0\u660e\u663e\u81f4\u764c\u6027\uff0c\u4f46\u9ad8\u5242\u91cf\uff08100 mg\/kg\/\u5929\uff09\u5582\u517b\u4f1a\u5bfc\u81f4\u5c0f\u9f20\u809d\u80bf\u7624\u7684\u53d1\u751f\u7387\u589e\u52a0\u3002<\/li>\n<\/ul>\n\n\n\n\n\n \u6d4b\u8bd5\u5bf9\u8c61<\/th>\n \u6d4b\u8bd5\u65b9\u6cd5<\/th>\n \u6d53\u5ea6\u8303\u56f4 (mg\/kg\/\u5929)<\/th>\n \u81f4\u764c\u6027\u8bc4\u4f30<\/th>\n<\/tr>\n<\/thead>\n \u5c0f\u9f20<\/td>\n \u957f\u671f\u5582\u517b<\/td>\n 10 – 100<\/td>\n 10 mg\/kg: \u65e0\u660e\u663e\u81f4\u764c\u6027\uff1b100 mg\/kg: \u6709\u81f4\u764c\u6027<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u7ed3\u8bba<\/h4>\n \u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u5728\u4f4e\u6d53\u5ea6\u4e0b\u5bf9\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22\u6d3b\u52a8\u65e0\u660e\u663e\u5f71\u54cd\uff0c\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u8f83\u4f4e\u7684\u6bd2\u6027\u3002\u7136\u800c\uff0c\u9ad8\u6d53\u5ea6\u7684TMG\u4f1a\u5bf9\u7ec6\u80de\u4ee3\u8c22\u3001\u7ec6\u80de\u5468\u671f\u548c\u7ec6\u80de\u51cb\u4ea1\u4ea7\u751f\u8d1f\u9762\u5f71\u54cd\uff0c\u5e76\u5177\u6709\u4e00\u5b9a\u7684\u81f4\u7a81\u53d8\u6027\u548c\u81f4\u764c\u6027\u3002\u56e0\u6b64\uff0c\u5728\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\uff0c\u5e94\u4e25\u683c\u63a7\u5236TMG\u7684\u4f7f\u7528\u6d53\u5ea6\uff0c\u907f\u514d\u9ad8\u6d53\u5ea6\u66b4\u9732\uff0c\u786e\u4fdd\u5176\u4f7f\u7528\u7684\u5b89\u5168\u6027\u3002<\/p>\n \u901a\u8fc7\u672c\u6587\u7684\u8be6\u7ec6\u89e3\u6790\u548c\u5177\u4f53\u5b9e\u9a8c\u6570\u636e\uff0c\u5e0c\u671b\u8bfb\u8005\u80fd\u591f\u5bf9TMG\u5bf9\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22\u6d3b\u52a8\u7684\u5f71\u54cd\u53ca\u5176\u5b89\u5168\u6027\u6709\u4e00\u4e2a\u5168\u9762\u800c\u6df1\u523b\u7684\u7406\u89e3\uff0c\u5e76\u6fc0\u53d1\u66f4\u591a\u7684\u7814\u7a76\u5174\u8da3\u548c\u521b\u65b0\u601d\u8def\u3002\u79d1\u5b66\u8bc4\u4f30\u548c\u5408\u7406\u5e94\u7528\u662f\u786e\u4fddTMG\u5728\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u53d1\u6325\u5927\u6f5c\u529b\u7684\u5173\u952e\u3002\u901a\u8fc7\u7efc\u5408\u63aa\u65bd\uff0c\u6211\u4eec\u53ef\u4ee5\u5927\u9650\u5ea6\u5730\u53d1\u6325TMG\u5728\u5404\u4e2a\u9886\u57df\u4e2d\u7684\u4ef7\u503c\u3002<\/p>\n \u53c2\u8003\u6587\u732e<\/h4>\n \n Toxicology in Vitro<\/strong>: Elsevier, 2018.<\/li>\n Toxicological Sciences<\/strong>: Oxford University Press, 2019.<\/li>\n Journal of Applied Toxicology<\/strong>: Wiley, 2020.<\/li>\n Mutation Research<\/strong>: Elsevier, 2021.<\/li>\n Carcinogenesis<\/strong>: Oxford University Press, 2022.<\/li>\n<\/ol>\n \u901a\u8fc7\u8fd9\u4e9b\u8be6\u7ec6\u7684\u4ecb\u7ecd\u548c\u8ba8\u8bba\uff0c\u5e0c\u671b\u8bfb\u8005\u80fd\u591f\u5bf9\u56db\u7532\u57fa\u80cd\u5728\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22\u6d3b\u52a8\u4e2d\u7684\u5f71\u54cd\u53ca\u5176\u5b89\u5168\u6027\u6709\u4e00\u4e2a\u5168\u9762\u800c\u6df1\u523b\u7684\u7406\u89e3\uff0c\u5e76\u6fc0\u53d1\u66f4\u591a\u7684\u7814\u7a76\u5174\u8da3\u548c\u521b\u65b0\u601d\u8def\u3002\u79d1\u5b66\u8bc4\u4f30\u548c\u5408\u7406\u5e94\u7528\u662f\u786e\u4fdd\u8fd9\u4e9b\u5316\u5408\u7269\u5728\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u53d1\u6325\u5927\u6f5c\u529b\u7684\u5173\u952e\u3002\u901a\u8fc7\u7efc\u5408\u63aa\u65bd\uff0c\u6211\u4eec\u53ef\u4ee5\u5927\u9650\u5ea6\u5730\u53d1\u6325TMG\u5728\u5404\u4e2a\u9886\u57df\u4e2d\u7684\u4ef7\u503c\u3002<\/p>\n \u6269\u5c55\u9605\u8bfb\uff1a<\/p>\n Addocat 106\/TEDA-L33B\/DABCO POLYCAT<\/u><\/a><\/p>\n Dabco 33-S\/Microporous catalyst<\/u><\/a><\/p>\n NT CAT BDMA<\/u><\/a><\/p>\n NT CAT PC-9<\/u><\/a><\/p>\n NT CAT ZR-50<\/u><\/a><\/p>\n 4-Acryloylmorpholine<\/u><\/a><\/p>\n N-Acetylmorpholine<\/u><\/a><\/p>\n Toyocat DT strong foaming catalyst pentamethyldiethylenetriamine Tosoh<\/a><\/p>\n Toyocat DMCH Hard bubble catalyst for tertiary amine Tosoh<\/a><\/p>\n TEDA-L33B polyurethane amine catalyst Tosoh<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" \u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u5bf9\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22\u6d3b\u52a8\u7684\u5f71\u54cd\u53ca\u5b89\u5168\u6027\u8bc4\u4ef7\u7814\u7a76\u62a5\u544a \u5f15\u8a00 \u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u78b1\u6027\u6709\u673a\u5316\u5408\u7269\uff0c\u4e0d\u4ec5\u5728\u6709\u673a\u5408\u6210\u548c\u836f\u7269\u5316\u5b66\u9886\u57df\u4e2d\u6709\u7740\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u8fd8\u56e0\u5176\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u53d7\u5230\u5173\u6ce8\u3002\u7136\u800c\uff0cTMG\u5bf9\u4eba\u4f53\u7ec6\u80de\u4ee3\u8c22 …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[1302,1301],"_links":{"self":[{"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/posts\/4612"}],"collection":[{"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/comments?post=4612"}],"version-history":[{"count":0,"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/posts\/4612\/revisions"}],"wp:attachment":[{"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/media?parent=4612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/categories?post=4612"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.vapingcc.com\/wp-json\/wp\/v2\/tags?post=4612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}